Photo by Linda Cronan

Find hotels in Medical Center District, San Antonio from $58

    Plan, book, stay with confidence
    bex rewards loyalty icon
    Be picky
    Search almost a million properties worldwide
    one key icon
    Treat yourself
    Save instantly and earn perks with One Key
    Learn about One Key
    today icon
    Change your mind
    Book hotels with free cancellation

Filter by

Popular filters
Popular filters
Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Popular locations
Popular locations
Meal plans available
Meal plans available
Amenities
Amenities
Accessibility
Accessibility
Traveler experience
Traveler experience

Discover 4,352 Medical Center District hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Outdoor pool, a heated pool, open 8:00 AM to 10:00 PM, free cabanas
Hotel Contessa
4.0 star property
8.8 out of 10, Excellent, (2747)
"Beautiful area, well cared for on the riverwalk. Saturday was very busy! We loved walking the riverwalk and seeing all the flowers and vegetation! Hotel was very nice and all employees very kind!"
The price is $174
$221 total
includes taxes & fees
May 26 - May 27
Hotel Contessa
Exterior
Omni La Mansion del Rio
4.0 star property
9.2 out of 10, Wonderful, (2138)
"Location"
The price is $188
$226 total
includes taxes & fees
May 27 - May 28
Omni La Mansion del Rio
Miscellaneous
Grand Hyatt San Antonio River Walk
4.0 star property
8.8 out of 10, Excellent, (1061)
"Close to the Riverwalk and very nice and clean"
The price is $188
$226 total
includes taxes & fees
May 27 - May 28
Grand Hyatt San Antonio River Walk
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free
Pool
Sonesta ES Suites San Antonio Downtown Alamo Plaza
3.0 star property
8.4 out of 10, Very Good, (1320)
"The property is a bit dated but good value for money overall. There is no daily cleaning service so you need to book this in advance. The staff are very friendly and helpful and the daily parking rate is pretty standard for downtown San Antonio"
The price is $104
$122 total
includes taxes & fees
Jun 2 - Jun 3
Sonesta ES Suites San Antonio Downtown Alamo Plaza
Outdoor pool, sun loungers
Hampton Inn San Antonio-Downtown (River Walk)
2.5 star property
8.2 out of 10, Very Good, (2639)
"Lots of people walking the area & homeless camps"
The price is $93
$110 total
includes taxes & fees
May 20 - May 21
Hampton Inn San Antonio-Downtown (River Walk)
Front of property
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
2.5 star property
8.6 out of 10, Excellent, (2993)
"Everything was good, I don’t have any complaint "
The price is $95
$113 total
includes taxes & fees
May 15 - May 16
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
Terrace/patio
Canopy by Hilton San Antonio Riverwalk
4.0 star property
9.2 out of 10, Wonderful, (1262)
"We loved it ! "
The price is $191
$230 total
includes taxes & fees
May 20 - May 21
Canopy by Hilton San Antonio Riverwalk
Meeting facility
Holiday Inn San Antonio - Riverwalk, an IHG Hotel
3.0 star property
8.4 out of 10, Very Good, (1480)
"It was nice and clean beautiful view from window"
The price is $125
$148 total
includes taxes & fees
May 26 - May 27
Holiday Inn San Antonio - Riverwalk, an IHG Hotel
Terrace/patio
AC Hotel by Marriott San Antonio Riverwalk
4.0 star property
8.4 out of 10, Very Good, (225)
"Room very clean, great location "
The price is $122
$144 total
includes taxes & fees
May 26 - May 27
AC Hotel by Marriott San Antonio Riverwalk
Exterior
Home2 Suites by Hilton San Antonio Downtown - Riverwalk, TX
3.0 star property
8.0 out of 10, Very Good, (1001)
"Great stsy"
The price is $127
$150 total
includes taxes & fees
May 30 - May 31
Home2 Suites by Hilton San Antonio Downtown - Riverwalk, TX
3 outdoor pools, cabanas (surcharge), sun loungers
Hyatt Regency Hill Country Resort & Spa
4.0 star property
8.8 out of 10, Excellent, (1004)
"Great service; hotel is pretty; but a little inconvenience about repairing "
The price is $280
$380 total
includes taxes & fees
May 19 - May 20
Hyatt Regency Hill Country Resort & Spa
Lobby
Clarion Pointe near Medical Center
2.5 star property
7.2 out of 10, Good, (1151)
"Good"
The price is $49
$58 total
includes taxes & fees
May 20 - May 21
Clarion Pointe near Medical Center
Exterior
O´Brien Historic Hotel
3.5 star property
7.8 out of 10, Good, (1006)
"Near everything "
The price is $110
$129 total
includes taxes & fees
May 20 - May 21
O´Brien Historic Hotel
Exterior
San Antonio Marriott Rivercenter on the River Walk
4.0 star property
8.8 out of 10, Excellent, (1002)
"Was nice that everything is a short walking distance to all the attractions "
The price is $194
$256 total
includes taxes & fees
May 26 - May 27
San Antonio Marriott Rivercenter on the River Walk
Restaurant
Element San Antonio Riverwalk
4.0 star property
8.6 out of 10, Excellent, (237)
"Simple design and very clean!"
The price is $114
$135 total
includes taxes & fees
May 20 - May 21
Element San Antonio Riverwalk
Lobby
Aloft San Antonio UTSA Area
3.0 star property
8.8 out of 10, Excellent, (545)
"Very nice property "
The price is $84
$99 total
includes taxes & fees
May 19 - May 20
Aloft San Antonio UTSA Area
Suite, 2 Queen Beds | Desk, laptop workspace, iron/ironing board, cribs/infant beds
Comfort Inn and Suites Near Medical Center
2.5 star property
7.0 out of 10, Good, (482)
"We found little roaches and ants in the room. Somebody called our room and knock our door at midnight????"
The price is $58
$68 total
includes taxes & fees
May 19 - May 20
Comfort Inn and Suites Near Medical Center
Lobby
SpringHill Suites San Antonio Downtown/Riverwalk Area
3.0 star property
8.2 out of 10, Very Good, (1003)
"Outstanding staff. Briefed us on what was going on in town, gave us tickets to an event. Were extremely friendly whenever we interacted with any of them. Great location. Nice breakfast"
The price is $101
$120 total
includes taxes & fees
May 30 - May 31
SpringHill Suites San Antonio Downtown/Riverwalk Area
Outdoor pool, sun loungers
Home2 Suites by Hilton San Antonio Riverwalk, TX
3.0 star property
8.6 out of 10, Excellent, (1002)
"Nice room."
The price is $127
$148 total
includes taxes & fees
May 27 - May 28
Home2 Suites by Hilton San Antonio Riverwalk, TX
Exterior
Hampton Inn & Suites San Antonio-Downtown/Market Square
2.5 star property
8.0 out of 10, Very Good, (1007)
"It was clean and comfortable to stay alone."
The price is $96
$117 total
includes taxes & fees
May 28 - May 29
Hampton Inn & Suites San Antonio-Downtown/Market Square
Don't see what you're looking for?
See all available properties in Medical Center District
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What is Medical Center District like?

Travelers are sure to enjoy a stay in San Antonio's Medical Center District neighborhood. Are you looking for Medical Center District travel tips? Be sure to check out USAA Corporate Office Headquarters and The San Antonio Art Institute while you're in the neighborhood.

What's a favorite place to stay in Medical Center District?

Based on Expedia customer reviews, Fairfield Inn & Suites by Marriott San Antonio Medical Center is the highest ranked property in Medical Center District. This hotel offers free breakfast and free parking. Other favorite options in the area include Atria Inn & Suites and Courtyard by Marriott Medical Center San Antonio.

How many hotels will I be able to find in Medical Center District?

Expedia has 127 hotels and other accommodations in Medical Center District to choose from, making this an ideal home base for exploring the greater San Antonio area.

If I need to cancel my hotel reservation in Medical Center District, will I receive a refund?

Yes! You'll find that most hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and be given a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to view top deals in Medical Center District.

Where can I learn more about changing or cancelling my trip to Medical Center District?

For more information about changing or cancelling your trip to Medical Center District, go to https://www.expedia.com/service/.

What can I see and do in this San Antonio neighborhood?

A few attractions you might want to check out while you're in Medical Center District are USAA Corporate Office Headquarters and The San Antonio Art Institute. Wonderland of the Americas Mall and First Unitarian Universalist Church are also worth a visit when you're out sightseeing in San Antonio.