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Compare hotels near Cairo Regional airport with room rates, reviews, and updated availability. Most hotels are fully refundable.
Quality Inn Cairo I-57
Quality Inn Cairo I-57
6.6 out of 10, (224)
The price is $76
$84 total
includes taxes & fees
Jul 10 - Jul 11
Cozy cabins on beautiful Horseshoe Lake
Cozy cabins on beautiful Horseshoe Lake
9.8 out of 10, Exceptional, (19)
The price is $115
$135 total
includes taxes & fees
Jun 12 - Jun 13
The Rested Duck Mallard Room
The Rested Duck Mallard Room
8.8 out of 10, Excellent, (15)
The price is $115
$143 total
includes taxes & fees
Jun 14 - Jun 15
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Super 8 by Wyndham Charleston/Sikeston East MO
Super 8 by Wyndham Charleston/Sikeston East MO
6.8 out of 10, (501)
The price is $62
$69 total
includes taxes & fees
Jun 12 - Jun 13
Eagle Inn Charleston
Eagle Inn Charleston
6.8 out of 10, (93)
The price is $70
$78 total
includes taxes & fees
Jun 21 - Jun 22
Quality Inn - Sikeston
Quality Inn - Sikeston
6.8 out of 10, (327)
The price is $63
$70 total
includes taxes & fees
Jun 17 - Jun 18
La Center Motel
La Center Motel
6.0 out of 10, (3)
The price is $61
$71 total
includes taxes & fees
Jun 12 - Jun 13
Solar Eclipse Festival at our Campground at Benton Speedway. April 6-8th 2024.
Solar Eclipse Festival at our Campground at Benton Speedway. April 6-8th 2024.
The price is $40
$60 total
includes taxes & fees
Jun 12 - Jun 13
Solar Eclipse Festival Campground at Benton Speedway. April 6-8th 2024.
Solar Eclipse Festival Campground at Benton Speedway. April 6-8th 2024.
10.0 out of 10, Exceptional, (1)
Days Inn and Suites by Wyndham Sikeston
Days Inn and Suites by Wyndham Sikeston
7.0 out of 10, Good, (1011)
The price is $70
$79 total
includes taxes & fees
Jul 2 - Jul 3
Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MO
9.4 out of 10, Exceptional, (1012)
The price is $99
$112 total
includes taxes & fees
Jun 16 - Jun 17
Beautiful Cabin Retreat
Beautiful Cabin Retreat
8.2 out of 10, Very Good, (39)
The price is $120
$192 total
includes taxes & fees
Jun 12 - Jun 13
Pear Tree Inn Sikeston
Pear Tree Inn Sikeston
9.4 out of 10, Exceptional, (1010)
The price is $94
$108 total
includes taxes & fees
Jun 16 - Jun 17
Best Western Plus Sikeston
Best Western Plus Sikeston
8.4 out of 10, Very Good, (1013)
The price is $98
$111 total
includes taxes & fees
Jun 12 - Jun 13
Travel Inn & Suites
Travel Inn & Suites
8.4 out of 10, Very Good, (527)
The price is $58
$66 total
includes taxes & fees
Jul 2 - Jul 3
Country Yard Inn and Suite
Country Yard Inn and Suite
7.4 out of 10, Good, (34)
The price is $62
$73 total
includes taxes & fees
Jun 25 - Jun 26
Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286
Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286
10.0 out of 10, Exceptional, (140)
Comfort Inn & Suites Sikeston I-55
Comfort Inn & Suites Sikeston I-55
8.4 out of 10, Very Good, (199)
The price is $94
$107 total
includes taxes & fees
Jul 7 - Jul 8
Charming cottage overlooking Lake Acre
Charming cottage overlooking Lake Acre
10.0 out of 10, Exceptional, (84)
The price is $150
$256 total
includes taxes & fees
Jun 16 - Jun 17
Super 8 by Wyndham Sikeston/Miner Area
Super 8 by Wyndham Sikeston/Miner Area
6.6 out of 10, (476)
The price is $60
$68 total
includes taxes & fees
Jun 17 - Jun 18
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent reviews of Cairo Regional hotelsExpedia verified reviews
5/5 Excellent
"The clerk was very kind"
A verified traveler from Valley Mills stayed at Days Inn and Suites by Wyndham Sikeston
Posted 21 hours ago
Hotels Close to Nearby Airports
Hotels near popular Cairo Attractions
- Shawnee National Forest
- Mississippi River
- Ohio River
- Southeast Missouri State University
- Isle Casino Cape Girardeau
- Riverfront Bridge Park
- Columbus-Belmont State Park
- Cape Rock Park
- Riverfront Park
- Henry N Barkhausen Cache River Wetlands Center
- The Book Bug
- Fort Defiance State Park
- eDen Spa & Salon
- Mound City National Cemetery
- Ullin City Hall
- Sikeston Depot Museum
- Fort D Historic Site
- Shawnee Community College
- Ballard Wildlife Management Area
- Central Park
Hotel options around Cairo Regional
- Drury Inn & Suites Sikeston, MO
- Beautiful Cabin Retreat
- Pear Tree Inn Sikeston
- Best Western Plus Sikeston
- Travel Inn & Suites
- Country Yard Inn and Suite
- Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286
- Comfort Inn & Suites Sikeston I-55
- Charming cottage overlooking Lake Acre
- Super 8 by Wyndham Sikeston/Miner Area
- Courtyard by Marriott Cape Girardeau Downtown
- Charming Home just minutes from Interstate and Mall
- Stylish chalet style home
- Beautiful newly renovated farm house overlooking 5 acre lake. ****New Rates ***
- Pole barn house
- Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel
- Next door to Wildlife Mgmt Area. Full kitchen, washer/dryer.
- Serenity South -- Gardens, River-Views, and Refreshing Space
- Little Blue Cottage on Spanish
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