You can't visit the area without admiring Statue of St George. This famous piece of artwork is on most sightseers' to-do lists.
You'll have no end of sightseeing choices when staying in Prague City Center. Statue of St George is a great place to start here, but there are lots of other interesting sights to experience. Charles Bridge, Old Town Square, and Prague Castle are not far from the work of art and will round out your day nicely.