Santee Vacation Rentals

    Plan, book, stay with confidence
    bex rewards loyalty icon
    Be picky
    Search almost a million properties worldwide
    one key icon
    Treat yourself
    Save instantly and earn perks with One Key
    Learn about One Key
    today icon
    Change your mind
    Book hotels with free cancellation

Vacation Rentals in Santee

Executive 2 BR/2 BA Lakefront Corner Suite Condo
Outdoor pool
Executive 2 BR/2 BA Lakefront Corner Suite Condo
9.4 out of 10, Exceptional, (22)
"My stay was amazing. It made me felt as if I was at home. The unit was very clean and well organized. I will definitely be booking this condo again in the near future."
Executive 2 BR/2 BA Lakefront Corner Suite Condo
Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!
Aerial view
Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!
10.0 out of 10, Exceptional, (19)
"My family and I really enjoyed staying here! There was plenty of room for everyone. Very clean which is a plus! We enjoyed having all the household essentials which made it much easier for us to make memories instead of running to get everything you need. Kids loved it!"
The price is $127
$357 total
includes taxes & fees
Jun 5 - Jun 6
Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!
Waterfront 3 Bedroom / 3 Bath Condo w/ Boat Slip Available
View from property
Waterfront 3 Bedroom / 3 Bath Condo w/ Boat Slip Available
10.0 out of 10, Exceptional, (33)
"Condo was clean, well supplied and comfortable with a wonderful balcony on the lake. Our family had a great time fishing on the dock and all over the lake in our bass boat and caught some bass and a catfish. Jerry, the host has been available and very responsive during our whole trip! This is or 4th vacation here and is our favorite stay at Santee."
Waterfront 3 Bedroom / 3 Bath Condo w/ Boat Slip Available
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free
Two Palms Lakehouse in Santee Just minutes from I95
Property grounds
Two Palms Lakehouse in Santee Just minutes from I95
7.6 out of 10, Good, (8)
"Great place for a couple days. We took advantage of the lake. Fishing was great for the grandchildren. I highly recommend this place if you enjoy being by the lake. Thank you."
Two Palms Lakehouse in Santee Just minutes from I95
Wyndham Vacation Resorts Lake Marion
Outdoor pool
Wyndham Vacation Resorts Lake Marion
4.0 star property
9.4 out of 10, Exceptional, (15)
"I enjoy my stay, customer service was exceptional. Will book again. "
Wyndham Vacation Resorts Lake Marion
Lakeview Condo close to Fishing, golfing, and hiking.
Property grounds
Lakeview Condo close to Fishing, golfing, and hiking.
Lakeview Condo close to Fishing, golfing, and hiking.
Bells Marina & Resort
Lake
Bells Marina & Resort
4.5 star property
9.0 out of 10, Wonderful, (40)
"We had the most relaxing trip at Bells Marina & Resort. Our room was clean, and we loved that the decor wasn’t typical generic hotel prints. Beware of the beds! They are so comfortable they practically suck you in. Everything was convenient to our room. The lake was right outside our door, which couldn’t have pleased us more. The store, diner, and rental boats were right there. We had planned some hiking, and we discussed renting an electric boat. In the end, we opted to sit by the lake and have...
The price is $92
$103 total
includes taxes & fees
Jun 17 - Jun 18
Bells Marina & Resort
Tom Charles Goat Island Fishing Retreat
Property grounds
Tom Charles Goat Island Fishing Retreat
9.8 out of 10, Exceptional, (36)
"I enjoyed my stay here. It is a very nice home. You can walk right out back and fish or just sit by the water. Water view when indoors is nice. Host was very responsive. Please know that you cannot take fish remains to the dump. They have signs, and they told us they do not accept them. When we asked how we should dispose of them, they told us they didn't know, but recommended we dig a hole. So, that was interesting. You only have access to the public dock, which isn't far. Short walk. I was...
Tom Charles Goat Island Fishing Retreat
Come Relax in the Country
Smart TV
Come Relax in the Country
10.0 out of 10, Exceptional, (29)
"While this location isn’t for everyone, I was so happy with it! We stayed here for a bee keeping class in Holly Hill. Property owner was so nice, the home was very clean, and we were able to bring our 2 dogs! The fenced in front yard was my favorite! I was also really happy with how well stocked it was- tin foil, good pots/pans, comfortable bed, waters & drinks, fans in every room, plenty of dishes, and the water pressure in the shower was fantastic. I also felt safe here. Perfect little getaway...
The price is $94
$154 total
includes taxes & fees
Jun 4 - Jun 5
Come Relax in the Country
SANITIZED! Lake Marion Lakefront Sandy Beach, Ramp, Sleeps 19, Wi-Fi Cable
On the beach, sun loungers
SANITIZED! Lake Marion Lakefront Sandy Beach, Ramp, Sleeps 19, Wi-Fi Cable
9.8 out of 10, Exceptional, (210)
"We start every year and absolutely love it"
SANITIZED! Lake Marion Lakefront Sandy Beach, Ramp, Sleeps 19, Wi-Fi Cable
Cozy Camping Cabin on Lake Marion near Congaree Nat Park
Exterior
Cozy Camping Cabin on Lake Marion near Congaree Nat Park
9.0 out of 10, Wonderful, (6)
"Cabin was as described very clean and comfortable and host was fantastic would recommend for any who wants more comfort than tent camping."
The price is $85
$143 total
includes taxes & fees
Jun 4 - Jun 5
Cozy Camping Cabin on Lake Marion near Congaree Nat Park
Deep water Lake Marion house. 4BR 2.5BA. Fish off dock. Nearby Golf. SUNSETS
Outdoor dining
Deep water Lake Marion house. 4BR 2.5BA. Fish off dock. Nearby Golf. SUNSETS
10.0 out of 10, Exceptional, (120)
"Great location on Lake Marion. Dock is set up for fishing and we caught a few big ones. House itself is exactly as described. Maybe not the Ritz, but it's Lake Marion. It's perfect for what it is. Very nice screened in porch looking out over the water. Almost a low country feel to the property and views. About 5 min from 1-95 and 10 min from Santee Food Lion. Bedrooms were comfortable and the kitchen was equipped appropriately. Great location for a golf weekend as well - plenty of decent courses...
Deep water Lake Marion house. 4BR 2.5BA. Fish off dock. Nearby Golf. SUNSETS
NEW LISTING! SANITIZED Lake Marion Lakefront! Ramp, Sleeps 13, Wi-Fi Cable
Exterior
NEW LISTING! SANITIZED Lake Marion Lakefront! Ramp, Sleeps 13, Wi-Fi Cable
9.8 out of 10, Exceptional, (156)
"This property was great for our needs and I would recommend it to anyone looking for a getaway or event which needs more capacity for guests."
NEW LISTING! SANITIZED Lake Marion Lakefront! Ramp, Sleeps 13, Wi-Fi Cable
Golf and Lake fun on Santee! Bring your boat or golf clubs!
Property grounds
Golf and Lake fun on Santee! Bring your boat or golf clubs!
9.8 out of 10, Exceptional, (20)
"This is the second time staying here. We Love it. It is so comfortable and welcoming. We had the best time with our family. Thank you again for all the comforts of home!"
Golf and Lake fun on Santee! Bring your boat or golf clubs!
Cozy Cottage Just a Block From a Boat Landing and a Beautiful Pristine Lake
Exterior
Cozy Cottage Just a Block From a Boat Landing and a Beautiful Pristine Lake
9.4 out of 10, Exceptional, (13)
"We came down to play a 3 day golf tournament. This place was perfect for us to rest and relax after a long day of golf. Place was clean, nice & quiet. We hope to stay here again."
Cozy Cottage Just a Block From a Boat Landing and a Beautiful Pristine Lake
Taw Caw Creek Rental - perfect for fishermen - NO PETS
Microwave, oven, stovetop, dishwasher
Taw Caw Creek Rental - perfect for fishermen - NO PETS
10.0 out of 10, Exceptional, (6)
"Very clean and great communication! Great area!"
Taw Caw Creek Rental - perfect for fishermen - NO PETS
Lake Marion's Big Red House. W/ Dock and Kayaks. Pet Friendly please read policy
Property grounds
Lake Marion's Big Red House. W/ Dock and Kayaks. Pet Friendly please read policy
9.6 out of 10, Exceptional, (64)
"We had an exceptional time at the red house with our group ranging from 2yr old to 89 year old. Everything we needed was provided dnd checkin was smooth."
Lake Marion's Big Red House. W/ Dock and Kayaks. Pet Friendly please read policy
Lakefront Summerton Getaway w/ Boat Dock + Pool!
TV, fireplace
Lakefront Summerton Getaway w/ Boat Dock + Pool!
8.0 out of 10, Very Good, (4)
"Very nice place. Very clean. Relaxing. And enjoyable.. thanknyou you!!! Will definitely recommend!!"
Lakefront Summerton Getaway w/ Boat Dock + Pool!
The Bunkhouse at St Julien - Vintage Waterfront Lake House
Property grounds
The Bunkhouse at St Julien - Vintage Waterfront Lake House
9.8 out of 10, Exceptional, (7)
"Had everything we needed. The hammock chairs were blissful. The lake view was awesome. Spotting Julian the alligator a couple of times was very cool. Mill Creek Food & Spirits at the marina was delicious with beach-y drinks. Just overall a relaxing, dog friendly vacation."
The Bunkhouse at St Julien - Vintage Waterfront Lake House
Idyllic Waterfront Escape w/ Private Boat Dock!
Property grounds
Idyllic Waterfront Escape w/ Private Boat Dock!
9.8 out of 10, Exceptional, (20)
"This place is great! We loved being on the lake!"
Idyllic Waterfront Escape w/ Private Boat Dock!
Don't see what you're looking for?
See all available properties in Santee
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other types of properties in Santee you may be interested in

Baymont by Wyndham Santee
Room, 2 Queen Beds, Non Smoking | Desk, blackout drapes, iron/ironing board, free WiFi
Baymont by Wyndham Santee
2.5 star property
7.8 out of 10, Good, (1321)
"Short stay while traveling to visit family. Initially thought it was going to be noisy from people moving back and forth with it being a ground floor room but ended up being very quiet. Room was comfortable although the A/C unit was clunky when it would cycle on and off. Overall a nice place to stay overnight."
The price is $75
$83 total
includes taxes & fees
Jun 4 - Jun 5
Baymont by Wyndham Santee
Fairfield Inn & Suites by Marriott Santee
Property amenity
Fairfield Inn & Suites by Marriott Santee
2.5 star property
9.8 out of 10, Exceptional, (1003)
"Very friendly staff. Great Thai restaurant right in front of property that we could walk to. Very clean bathroom and bedroom "
The price is $142
$158 total
includes taxes & fees
Jun 10 - Jun 11
Fairfield Inn & Suites by Marriott Santee
Tru By Hilton Santee
Room, 2 Queen Beds, Accessible, Bathtub (Mobility & Hearing) | Free WiFi, bed sheets
Tru By Hilton Santee
2.5 star property
9.0 out of 10, Wonderful, (119)
"Amazing hotel. So clean and comfortable. Staff very friendly. "
The price is $114
$127 total
includes taxes & fees
Jun 10 - Jun 11
Tru By Hilton Santee
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Everything you need to know about Santee vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Santee vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Santee vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Santee vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Santee. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Santee in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $85 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Santee rentals

At Expedia, we put the best Santee vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Santee rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Santee vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Santee. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Frequently asked questions

Can I find vacation rentals in Santee?

Yes, we offer vacation rentals near the most popular points of interest in Santee, or you can select a more remote option if you'd like a relaxing place to stay. Tourists appreciate the top-notch restaurants and coffeehouses in Santee. Make sure you have time to check out the golf courses and lake views during your trip.

What are some of the best vacation home rentals in Santee?

Mary's Place​ -A waterfront retreat on Beautiful Lake Marion : This vacation home rental outside of Santee is located on a lake and has a fireplace, a patio, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. It offers a garden, a selection of games, and a spa tub so you can immerse yourself in your vacation.

How many vacation rentals are there in Santee?

Expedia has 7 vacation rentals for your stay in Santee.

What can I see and do in Santee?

Santee State Park and Lake Marion are a couple of lovely local spots to get outside and enjoy nature. Santee Cooper Country Club and Santee Outlets are other places to visit while you're in town.

What are vacation rentals like in Santee?

Vacation rentals are private accommodations you can book for several days or more in Santee. Vacation rentals feature amenities like kitchens and laundry facilities so you'll feel just like you're at home. If you're concerned about a sanitized environment, a vacation rental can provide a sense of safety away from public hotel elevators and bustling concierge desks while still allowing you the experience of travel. You'll also get more space in a vacation rental than in a standard hotel, which is another reason why a vacation rental is a great choice for family gatherings.

Recent reviews of Santee properties
Expedia verified reviews

Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee

5/5 Excellent
"Very friendly staff. Great Thai restaurant right in front of property that we could walk to. Very clean bathroom and bedroom "
A verified traveler stayed at Fairfield Inn & Suites by Marriott Santee
Posted 4 days ago
Fairfield Inn & Suites by Marriott Santee