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Find hotels in Defiance, MO from $62

Check Defiance hotel prices

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May 28 - May 29
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May 29 - May 30
This weekend
May 31 - Jun 2
Next weekend
Jun 7 - Jun 9

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Compare 793 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Exterior
Baymont by Wyndham Warrenton
2.5 star property
7.2 out of 10, Good, (804)
"They was remodeling so other then that it was great"
The price is CNY913
CNY1,045 total
includes taxes & fees
Jun 7 - Jun 8
Baymont by Wyndham Warrenton
Lobby
Quality Inn
2.5 star property
8.2 out of 10, Very Good, (601)
"Trucks top noise made it hard to sleep. The under construction was mismatched, but still clean & handled well. Food in breakdast area was minimal options."
The price is CNY1,232
CNY1,391 total
includes taxes & fees
Jun 7 - Jun 8
Quality Inn
Lobby
Economy Inn Wentzville
2.0 star property
6.2 out of 10, (357)
"Convenient stop right off of I-70 halfway between Colorado and Maryland. Much appreciated. "
Economy Inn Wentzville
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In-room safe, desk, laptop workspace, blackout drapes
Super 8 by Wyndham Warrenton
2.0 star property
7.4 out of 10, Good, (476)
"Overall decent experience"
The price is CNY819
CNY937 total
includes taxes & fees
Jun 7 - Jun 8
Super 8 by Wyndham Warrenton
Exterior
Holiday Inn Express & Suites Wentzville St Louis West, an IHG Hotel
2.5 star property
9.4 out of 10, Exceptional, (580)
"Everything was fine apart from the filter in our air conditioner, which was caked with dust and made the room musty. I would recommend changing those out more often."
The price is CNY1,514
CNY1,784 total
includes taxes & fees
Jun 7 - Jun 8
Holiday Inn Express & Suites Wentzville St Louis West, an IHG Hotel
Lobby
Best Western Plus Washington Hotel
2.5 star property
9.0 out of 10, Wonderful, (453)
"Hotel was extremely clean, front desk staff was nice, breakfast was wonderful with a espresso coffee maker for mochas or lattes, beds were comfy..best hotel we have stayed at in a long time. We had the suite with 3 beds and the room was huge"
Best Western Plus Washington Hotel
Room, 2 Queen Beds, Non Smoking | In-room safe, desk, blackout drapes, iron/ironing board
Super 8 by Wyndham Washington
2.0 star property
8.4 out of 10, Very Good, (557)
"The property is immaculate, updated and an excellent value for the price. Breakfast was not fancy, but very good. "
The price is CNY906
CNY1,031 total
includes taxes & fees
Jun 7 - Jun 8
Super 8 by Wyndham Washington
Exterior
Hampton Inn St. Louis Wentzville
2.5 star property
9.0 out of 10, Wonderful, (514)
"This is a fairly new Hampton, in a good location with lots of free parking. As a Hampton property, you expect it to be nice neat and clean. Our room smelled like dirty feet and the tile in the bathroom had a trail of dirt that did not look like it had ever been cleaned. Our shoes stuck to the tile so needless to say we didn’t walk barefoot in the room. I took a rag and cleaned a spot on the tile so someone would hopefully see how dirty it was and mop. I did tell the checkout person when we were...
The price is CNY1,496
CNY1,712 total
includes taxes & fees
Jun 7 - Jun 8
Hampton Inn St. Louis Wentzville
Lobby
Holiday Inn Express Warrenton, an IHG Hotel
2.5 star property
9.2 out of 10, Wonderful, (438)
"Nice and quiet. Clean, comfortable, and service was amazing"
The price is CNY1,405
CNY1,609 total
includes taxes & fees
Jun 7 - Jun 8
Holiday Inn Express Warrenton, an IHG Hotel
Reception
Fairfield Inn & Suites Wentzville
2.5 star property
9.0 out of 10, Wonderful, (505)
"The staff was friendly. The place was clean and the breakfast was good.❣️"
The price is CNY1,514
CNY1,718 total
includes taxes & fees
Jun 7 - Jun 8
Fairfield Inn & Suites Wentzville
Balcony view
The Inn at Elijah McLeans
4.0 star property
9.2 out of 10, Wonderful, (88)
"Quaint inn with a clubhouse next door for drinks, pizza and snacks. Nice outdoor seating at clubhouse with view of the river. This is about a 2 block walk away from three restaurants. Would stay again. "
The Inn at Elijah McLeans
Property grounds
Pinckney Bend Bed & Breakfast
3.0 star property
9.6 out of 10, Exceptional, (85)
"Originally, we planned to stay in the town of Hermann but decided to browse the area for other nearby alternatives. We very much enjoyed our stay and couldn't have been happier. We lucked out with a few days of nearly perfect weather and sunshine. The views off the deck were amazing. Breakfast was exceptional—one of the best of any BNB we've ever visited. Tricia was very knowledgable and gave us great recommendations for things happening in a few surrounding towns that turned out to be fun and...
Pinckney Bend Bed & Breakfast
Family Studio Suite (No Elevator Access) | Egyptian cotton sheets, premium bedding, down comforters, pillowtop beds
River Sirens Hotel
2.5 star property
9.8 out of 10, Exceptional, (107)
"This was our second stay. Although laid out differently, each of the rooms are essentially the same. This time we stayed on the first floor and fully expected a "basement experience". Not to be had! Never would have realized we were partially underground. As usual our room was ready, clean as an operating room and comfortable. The newest addition is the ar ade/bar caddy corner to the hotel. We spent a few nights enjoying libations and games!"
The price is CNY2,166
CNY2,466 total
includes taxes & fees
Jun 7 - Jun 8
River Sirens Hotel
Aerial view
TheOutPostInn Bed&Breakfast - The Blue Victorian
10.0 out of 10, Exceptional, (2)
"In downtown, quaint Marthasville MO, this old renovated home was a perfect getaway for my wife and I. The room was clean, the bed was huge and the amenities were spot on. The breakfast in the morning was a major bonus as well."
TheOutPostInn Bed&Breakfast - The Blue Victorian
Front of property
Central Hotel
3.5 star property
9.8 out of 10, Exceptional, (93)
"Absolutely loved the Central Hotel! This is a beautifully renovate hotel. It has so much charm. Each room is unique with a tasteful mixture of modern convenience and a decorative touch of years gone by. Jeannie keeps the hotel clean and makes sure you feel welcome. There is an upscale Continental breakfast with Jeannie's personal service to make sure you have what you need. Wish we had planned another night there. The town is charming with a down-home feel. If you are looking for a...
The price is CNY1,123
CNY1,227 total
includes taxes & fees
Jun 7 - Jun 8
Central Hotel
1 bedroom, free WiFi, bed sheets
TheOutPostInn Bed&Breakfast - The Purple Victorian
TheOutPostInn Bed&Breakfast - The Purple Victorian
Exterior
Private entry, lower area only with gameRoom, living room, bedroom and bathroom.
10.0 out of 10, Exceptional, (1)
"Not much available for cooking but we made it work. Boiled crab legs n baked biscuits on the grill! Beautiful weekend with the snow storm and views"
Private entry, lower area only with gameRoom, living room, bedroom and bathroom.
Interior
TheHistorian! Daniel Boone Country-Marthasville,MO
9.4 out of 10, Exceptional, (9)
"Very clean. Nicely decorated. Very easy check in"
TheHistorian! Daniel Boone Country-Marthasville,MO
Interior
The Cyclist! Katy Trail comfort in Marthasville,MO
10.0 out of 10, Exceptional, (6)
"Wonderful place to get away to and relax!"
The Cyclist! Katy Trail comfort in Marthasville,MO
Interior
The Wineaux! Wine Country charm in Marthasville,MO
9.2 out of 10, Wonderful, (5)
"Got in late enjoyed a good bed and shower after 2 days of pedaling."
The Wineaux! Wine Country charm in Marthasville,MO
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See all available properties in Defiance
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More cheap stays in Defiance

Days Inn and Suites by Wyndham St. Louis/Westport Plaza

Days Inn and Suites by Wyndham St. Louis/Westport Plaza

1970 Craig Rd, Maryland Heights, MO
The price is $64 per night from Jun 4 to Jun 5
$64
$74 total
includes taxes & fees
Jun 4 - Jun 5
4.6/10 (1,004 reviews)

Stay near popular Defiance attractions

Image for St. Louis Union Station

St. Louis Union Station

4/5(615 reviews)

You can learn about the local history of St. Louis when you make a stop at a well-known site like St. Louis Union Station. Experience the area's great live music or attend a baseball game.

See properties
St. Louis Union Station

Defiance Travel Info

Number of reviews
5,363
Accommodation
793 hotels
Highest price
$156
Lowest price
$62
Reasons to visit
Augusta Winery, Montelle Winery and Chandler Hill Vineyards
Hotels with nearby wineries
3

Frequently asked questions

What's the best place to stay in Defiance?

Hollywood Casino & Hotel St. Louis, located 18.1 mi (29.2 km) from the heart of Defiance, is a top choice for your stay based on our traveler data. Other good choices for your stay in the area are La Quinta Inn & Suites by Wyndham St. Louis Westport and The Wildwood Hotel. See all available top hotels, or vacation rentals in Defiance.

What's the top vacation rental in Defiance?

The St. Charles Guest House, lovely historic home, fun for families and groups: Visitors like this Defiance vacation home rental. It is located on a river and offers a fireplace, air-conditioning, and laundry facilities to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. See all vacation rentals in Defiance.

If I need to cancel my hotel reservation in Defiance, will I receive a refund?

Yes, the majority of hotel reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a reservation that's non-refundable, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.

Where can I learn more about changing or cancelling my trip to Defiance?

For more information about changing or cancelling your trip to Defiance, head over to our customer service page.

Where is the best hotel to stay with easy access to August A. Busch Memorial Conservation Area?

Sleep Inn & Suites O'Fallon MO - Technology Drive is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an indoor pool. It's located 2.6 mi (4.3 km) from August A. Busch Memorial Conservation Area. Other good options within a few miles include Hilton Garden Inn St. Louis/O'Fallon MO and Holiday Inn Express St. Louis West - O'Fallon, an IHG Hotel.

What about the best place to stay near Chandler Hill Vineyards?

One of the top choices for your stay is The Wildwood Hotel, located 10 mi (16.1 km) from Chandler Hill Vineyards, and this 3.5-star hotel offers free breakfast and an indoor pool.

What are some accommodations with pools in Defiance?

La Quinta Inn & Suites by Wyndham St. Louis Westport: Hotel, 12-minute walk from Westport Plaza. Offers continental, an outdoor pool, and complimentary wired internet access. The Wildwood Hotel and Sonesta ES Suites St. Louis - Chesterfield are two additional hotels that offer an onsite pool. View all hotels with pools in Defiance.

What's the best place to stay near Lambert-St. Louis International Airport (STL)?

Marriott St. Louis Airport is a popular 3.5-star hotel featuring a restaurant and an outdoor pool. It's located a short 0.3 mi (0.5 km) from Lambert-St. Louis Intl. Airport. Other good choices within close proximity to the airport include Pear Tree Inn Airport - St. Louis - St. Ann, MO and Drury Inn & Suites St. Louis Airport.

What's it like to stay in Defiance?

Visitors can enjoy all that Defiance has to offer including the wineries and parks. A top sight in the area is Six Flags St. Louis. In Defiance, there are 12 hotels and other accommodations to choose from. Find out more about Defiance.

What is there to see in Defiance?

Natural beauty is on display at Missouri River, August A. Busch Memorial Conservation Area, and Broemmelsiek Park. Additionally, you'll find Six Flags St. Louis in the area. Check out what more to see and do in Expedia's Defiance guide.

What's the seasonal weather like in Defiance?

The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 38°F. Average annual precipitation for Defiance is 48 inches.

Recent reviews of Defiance hotels
Expedia verified reviews

Country Inn & Suites by Radisson, St. Charles, MO

Country Inn & Suites by Radisson, St. Charles, MO

5/5 Excellent
"Great hotel with friendly staff in a great location! My family enjoyed the breakfast options, it was well stocked and a variety of options. The hotel was within walking distance of Main Street St. Charles and an easy drive into St. Louis. Rooms were clean and my kids loved the indoor pool. Our only small complaint was that the WiFi in our room did not work well and we didn’t have great cell service but the WiFi worked fine in the lobby and breakfast area, so not a huge issue but might be if working remote during your stay. Would definitely return here!"
A verified traveler stayed at Country Inn & Suites by Radisson, St. Charles, MO
Posted 8 hours ago
Country Inn & Suites by Radisson, St. Charles, MO