Find 5 Star Hotels in Florida Keys from $299
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Compare Florida Keys 5 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.
Isla Bella Beach Resort & Spa
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Hawks Cay Resort
Ready for an incredible adventure? Add an extra layer of luxury on your next trip to Florida Keys by treating yourself to the best of the best when it comes to lodging. It's an ideal combination. After all, you love the finer things in life, both at home and when you book a getaway. You'll join the multitudes of vacationers who have made Florida Keys so popular in the last year. There's no reason to delay a getaway to Florida Keys any longer. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. Book one of Expedia's luxurious 5-star hotels in Florida Keys and get ready to be pampered like never before. Don't wait any longer!
Get a Great Deal on 5-Star Hotels in Florida Keys
You'll have a fantastic time at one of these 5-star hotels. Exceptional service, delicious meals, and personalized service are all waiting for you. Our numerous hotels in the area will ensure you find the perfect space to kick back after a long day. You can also look forward to an outstanding experience and fantastic customer care, so get ready to kick back and indulge. What creature comforts do you want in your lodging? 24-hour room service, so you can order that filet mignon in the wee hours of the morning? A reflexology treatment that will leave you feeling refreshed and alive? Butler services? Whatever it is your heart desires, you're bound to find it here.
Ready for experiences outside your hotel room? We've got you covered. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what you end up doing, the 5-star hotels in Florida Keys are waiting for you to relax after a busy day. Ready to learn more? Then check out our listings and pick the perfect accommodation for your needs.
Your Getaway Starts Today
Numerous visitors make Florida Keys the place to vacation. Why not join their ranks? If you've been dreaming about a vacation set here, then go ahead and book it. A surge in interest means these great hotel rooms will go quickly. Your great getaway is just a mouse-click away. Choose one of Expedia's Florida Keys 5-star hotels today and soothe yourself in luxe surroundings tomorrow.
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Florida Keys Hotels by Star Rating
Stay near popular Florida Keys attractions
- Duval Street
- Mallory Square
- John Pennekamp Coral Reef State Park
- Sombrero Beach
- Smathers Beach
- Southernmost Point
- South Beach
- Ernest Hemingway Home and Museum
- Fort Zachary Taylor Historic State Park
- Jimmy Johnson's Big Chill
- Key West Golf Club
- Seven Mile Bridge
- Clarence S. Higgs Memorial Beach Park
- Baker's Cay Resort Beach
- Stock Island Yacht Club & Marina
- Biscayne National Park
- Boca Chica Nude Beach
- Florida Keys Visitor Center
- Harry S. Truman Little White House
- Key West Butterfly and Nature Conservatory
More Hotel Options in Florida Keys
- Beach Hotels (236)
- Business Hotels (87)
- Cheap Hotels (92)
- Family Hotels (208)
- Fishing Resorts & Hotels (121)
- Golf Hotels (121)
- Historic Hotels (123)
- Hotel Wedding Venues (98)
- Hotel with a Concierge (130)
- Hotels & Resorts for Couples (267)
- Hotels with Air Conditioning (292)
- Hotels with Balconies (200)
- Hotels with Bars (164)
- Hotels with Free Breakfast (97)
- Hotels with Free Parking (187)
- Hotels with Free Wifi (212)
- Hotels with Hot Tubs (113)
- Hotels with Kitchenettes (60)
- Hotels with Laundry Facilities (134)
- Hotels with Restaurants (211)
- Hotels with Tennis Courts (56)
- Hotels with a Gym (76)
- Hotels with a Pool (246)
- Hotels with a View (157)
- Hotels with an Outdoor Pool (236)
- Luxury Hotels (120)
- Non-Smoking Hotels (138)
- Oceanfront Hotels (80)
- Pet-friendly Hotels (73)
- Quiet Resorts & Hotels (89)
- Resorts & Hotels with Spas (99)
- Romantic Hotels (169)
More Accommodation Types in Florida Keys
- Vacation Homes in Florida Keys (723)
- Condo Rentals in Florida Keys (144)
- Villas in Florida Keys (60)
- Apartments in Florida Keys (32)
- Cottages in Florida Keys (32)
- Resorts in Florida Keys (12)
- RV Parks in Florida Keys (10)
- Motels in Florida Keys (9)
- Houseboats in Florida Keys (8)
- Aparthotels in Florida Keys (5)
- Cabin Rentals in Florida Keys (4)
- Guest Houses in Florida Keys (4)
- Lodges in Florida Keys (2)
- B&B in Florida Keys (1)
Explore more hotels
- Coconut Cay Resort & Marina
- Lime Tree Bay Resort
- Amara Cay Resort
- Fairfield Inn & Suites by Marriott Marathon Florida Keys
- Playa Largo Resort & Spa, Autograph Collection
- Reefhouse Resort & Marina
- Kingsail Resort
- Rock Reef Resort
- Aqua Lodge Rentals At Coconut Cay
- Key Largo Inn
- Banana Bay Resort & Marina
- La Siesta Resort & Villas
- Courtyard by Marriott Faro Blanco Resort
- Hadley Resort and Marina
- Islander Resort
- The Pelican Key Largo Cottages
- Rainbow Bend Resort
- Tranquility Bay Beachfront Hotel and Resort
- Ocean Pointe Suites at Key Largo
- Sugarloaf Key Hotel at KOA Resort